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4kgg
From Proteopedia
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| - | + | {{STRUCTURE_4kgg| PDB=4kgg | SCENE= }} | |
| + | ===Crystal structure of light mutant2 and dcr3 complex=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/TNF6B_HUMAN TNF6B_HUMAN]] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.<ref>PMID:21300286</ref> [[http://www.uniprot.org/uniprot/TNF14_HUMAN TNF14_HUMAN]] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. | ||
| - | + | ==About this Structure== | |
| + | [[4kgg]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_acetobutylicum Clostridium acetobutylicum] and [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KGG OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Clostridium acetobutylicum]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Almo, S C.]] | ||
| + | [[Category: Bonanno, J B.]] | ||
| + | [[Category: IFN, Atoms-to-Animals:.The Immune Function Network.]] | ||
| + | [[Category: Liu, W.]] | ||
| + | [[Category: NYSGRC, New York Structural Genomics Research Consortium.]] | ||
| + | [[Category: Nathenson, S G.]] | ||
| + | [[Category: Prakash, R.]] | ||
| + | [[Category: Toro, R.]] | ||
| + | [[Category: Zhan, C.]] | ||
| + | [[Category: Atoms-to-animals: the immune function network]] | ||
| + | [[Category: Bind tnf receptor hvem and ltbr]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Cytokine-signaling protein complex]] | ||
| + | [[Category: Dcr3]] | ||
| + | [[Category: Ifn]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Jelly-roll fold]] | ||
| + | [[Category: Light]] | ||
| + | [[Category: Ltbr]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: N-glycosylation]] | ||
| + | [[Category: New hvem]] | ||
| + | [[Category: New york structural genomics research consortium]] | ||
| + | [[Category: Nysgrc]] | ||
| + | [[Category: Protein structure initiative]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Secreted protein]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Tnf]] | ||
| + | [[Category: Tnf14]] | ||
| + | [[Category: Tnfr]] | ||
Revision as of 21:03, 7 August 2013
Contents |
Crystal structure of light mutant2 and dcr3 complex
Function
[TNF6B_HUMAN] Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.[1] [TNF14_HUMAN] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
About this Structure
4kgg is a 4 chain structure with sequence from Clostridium acetobutylicum and Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Zhan C, Patskovsky Y, Yan Q, Li Z, Ramagopal U, Cheng H, Brenowitz M, Hui X, Nathenson SG, Almo SC. Decoy Strategies: The Structure of TL1A:DcR3 Complex. Structure. 2011 Feb 9;19(2):162-71. PMID:21300286 doi:10.1016/j.str.2010.12.004
Categories: Clostridium acetobutylicum | Homo sapiens | Almo, S C. | Bonanno, J B. | IFN, Atoms-to-Animals:.The Immune Function Network. | Liu, W. | NYSGRC, New York Structural Genomics Research Consortium. | Nathenson, S G. | Prakash, R. | Toro, R. | Zhan, C. | Atoms-to-animals: the immune function network | Bind tnf receptor hvem and ltbr | Cytokine | Cytokine-signaling protein complex | Dcr3 | Ifn | Immune system | Jelly-roll fold | Light | Ltbr | Membrane | N-glycosylation | New hvem | New york structural genomics research consortium | Nysgrc | Protein structure initiative | Psi-biology | Secreted protein | Structural genomic | Tnf | Tnf14 | Tnfr
