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4kmx
From Proteopedia
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| - | + | {{STRUCTURE_4kmx| PDB=4kmx | SCENE= }} | |
| + | ===Human folate receptor alpha (FOLR1) at acidic pH, hexagonal form=== | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:[http://omim.org/entry/613068 613068]]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/FOLR1_HUMAN FOLR1_HUMAN]] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. | ||
| - | + | ==About this Structure== | |
| + | [[4kmx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KMX OCA]. | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: III, C E.Dann.]] | ||
| + | [[Category: Wibowo, A S.]] | ||
| + | [[Category: 5-methyltetrahydrofolate]] | ||
| + | [[Category: Antifolate]] | ||
| + | [[Category: Folate receptor]] | ||
| + | [[Category: Folate receptor alpha]] | ||
| + | [[Category: Folate-conjugate]] | ||
| + | [[Category: Folate]] | ||
| + | [[Category: Folic acid]] | ||
| + | [[Category: Folr1]] | ||
| + | [[Category: Gpi-anchored protein on eukaryotic membrane]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transport protein]] | ||
Revision as of 21:03, 7 August 2013
Contents |
Human folate receptor alpha (FOLR1) at acidic pH, hexagonal form
Disease
[FOLR1_HUMAN] Neurodegenerative syndrome due to cerebral folate transport deficiency. Neurodegeneration due to cerebral folate transport deficiency (NCFTD) [MIM:613068]: A neurodegenerative disorder resulting from brain-specific folate deficiency early in life. Onset is apparent in late infancy with severe developmental regression, movement disturbances, epilepsy and leukodystrophy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Function
[FOLR1_HUMAN] Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells.
About this Structure
4kmx is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
