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Thioesterase
From Proteopedia
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[[1q4t]] - ArTE + 4-hydroxyphenyl CoA<br /> | [[1q4t]] - ArTE + 4-hydroxyphenyl CoA<br /> | ||
[[1q4u]] - ArTE + 4-hydroxybenzyl CoA<br /> | [[1q4u]] - ArTE + 4-hydroxybenzyl CoA<br /> | ||
| - | [[3r32]], [[3r35]], [[3r37]], [[3r38]], [[3r3c]], [[3r3d]], [[3r3f]] - ArTE (mutant) + 4-hydroxyphenacyl CoA<br /> | + | [[3r32]], [[3r35]], [[3r37]], [[3r38]], [[3r3c]], [[3r3d]], [[3r3f]], [[3tea]] - ArTE (mutant) + 4-hydroxyphenacyl CoA<br /> |
[[3r3a]] - ArTE (mutant) + 4-hydroxybenzoate<br /> | [[3r3a]] - ArTE (mutant) + 4-hydroxybenzoate<br /> | ||
[[3r34]] - ArTE (mutant) + CoA<br /> | [[3r34]] - ArTE (mutant) + CoA<br /> | ||
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[[3kv7]], [[3kv8]], [[3p2r]], [[3p2s]] – ScTE + acetate derivative<br /> | [[3kv7]], [[3kv8]], [[3p2r]], [[3p2s]] – ScTE + acetate derivative<br /> | ||
[[3kvu]] – ScTE + acetyl-CoA<br /> | [[3kvu]] – ScTE + acetyl-CoA<br /> | ||
| - | [[3kvz]] – ScTE + FAcOPan<br /> | + | [[3kvz]], [[3kw1]] – ScTE + FAcOPan<br /> |
[[3kx7]], [[3fx8]], [[3p2q]] – ScTE <br /> | [[3kx7]], [[3fx8]], [[3p2q]] – ScTE <br /> | ||
[[3p3f]] – ScTE (mutant) <br /> | [[3p3f]] – ScTE (mutant) <br /> | ||
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''USP 7'' | ''USP 7'' | ||
| - | [[2ylm]] – hUSP <BR /> | + | [[2ylm]], [[2f1z]] – hUSP <BR /> |
[[2kvr]] – hUSP UBL domain - NMR <BR /> | [[2kvr]] – hUSP UBL domain - NMR <BR /> | ||
| + | [[1nb8]] – hUSP catalytic domain <BR /> | ||
| + | [[1yze]] – hUSP N terminal domain <BR /> | ||
| + | [[2f1w]] – hUSP TRAF-like domain <BR /> | ||
| + | [[2f1x]] – hUSP TRAF-like domain + p53 peptide<BR /> | ||
| + | [[2foj]], [[2foo]] – hUSP N terminal domain + p53 peptide<BR /> | ||
| + | [[2f1y]] – hUSP TRAF-like domain + MDM2 peptide<BR /> | ||
| + | [[2fop]] – hUSP N terminal domain + MDM2 peptide<BR /> | ||
| + | [[1nbf]] – hUSP catalytic domain + ubiquitin aldehyde<BR /> | ||
| + | [[1yy6]] – hUSP N terminal domain + Epstein-Barr nuclear antigen<BR /> | ||
[[3mqr]], [[3mqs]] – hUSP + peptide <BR /> | [[3mqr]], [[3mqs]] – hUSP + peptide <BR /> | ||
[[2xxn]] – hUSP + VIRF-4 <BR /> | [[2xxn]] – hUSP + VIRF-4 <BR /> | ||
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''USP 8'' | ''USP 8'' | ||
| + | [[2a9u]] – hUSP N terminal domain <BR /> | ||
| + | [[2gfo]] – hUSP catalytic domain <BR /> | ||
[[2gwf]] – hUSP rhodanese domain + ring finger protein <BR /> | [[2gwf]] – hUSP rhodanese domain + ring finger protein <BR /> | ||
[[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]] – hUSP + SUS1 + SAGA-associated factors 11, 73 <BR /> | [[3mhh]], [[3m99]], [[4fip]], [[4fjc]], [[4fk5]] – hUSP + SUS1 + SAGA-associated factors 11, 73 <BR /> | ||
Revision as of 11:46, 12 August 2013
Thioesterase (TE) catalyzes the break of an ester bond to produce acid and alcohol at a thiol group. TEs are substrate-specific. Palmitoyl protein TE removes fatty acids like palmitate from modified cysteine residues during lysosomal degradation. 4-hydroxybenzoyl-CoA TE converts 4-hydroxybenzoyl-CoA to 4-hydroxybenzoate and CoA. Acyl-CoA TE hydrolyzes acyl-CoA to the fatty acid and CoA and is involved in lipid metabolism. Fluoroacetyl-CoA TE from Streptomyces cattleya hydrolyzes fluoroacetyl-CoA thus preventing it from being metabolized to the lethal 4-hydroxy-trans-aconitate. Ubiquitin TE (USP) removes conjugated ubiquitin from proteins thus regulating protein level by preventing their degradation.
3D structures of thioesterase
Updated on 12-August-2013
Maristoyl-ACP-specific TE
1tht – TE – Vibrio harveyi
4-hydroxybenzoyl-CoA TE
1bvq – PsTE – Pseudomonas
1lo7 – PsTE + 4-hydroxyphenyl CoA
1lo9 - PsTE (mutant) + 4-hydroxybenzoyl CoA
1lo8 - PsTE + 4-hydroxybenzyl CoA
1q4s - ArTE + 4-hydroxybenzoate – 'Arthrobacter'
1q4t - ArTE + 4-hydroxyphenyl CoA
1q4u - ArTE + 4-hydroxybenzyl CoA
3r32, 3r35, 3r37, 3r38, 3r3c, 3r3d, 3r3f, 3tea - ArTE (mutant) + 4-hydroxyphenacyl CoA
3r3a - ArTE (mutant) + 4-hydroxybenzoate
3r34 - ArTE (mutant) + CoA
Palmitoyl protein TE
1eh5 – bTE1 + Palmitate – bovine
1ei9 – bTE1
1exw – bTE1 + hexadecylsulfonyl fluoride
1pja – hTEII – human
3gro - hTEI
Acyl-CoA TE
1c8u – EcTEII – Escherichia coli
1ivn – EcTEI
1jrl – EcTEI (mutant)
1j00 – EcTEI + diethyl phosphono derivative
1v2g, 1u8u - EcTEI + octanoic acid
2v1o – mTE7 hotdog domain – mouse
2q2b – mTE7 C terminal
3hlk – hTE2
3k2i – hTE4
2qq2 - hTE7 C terminal
3fo5 – hTE11 START domain
3b7k – hTE12
3rd7 – TE – Mycobacterium avium
3u0a – TEII – Mycobacterium marinum
1tbu – TE N terminal (peroximal) – yeast
Acyl protein TE
1fj2 – EcTEI
Acyl-ACP TE
2ess – TE – Bacterioides thetaiotaomicron
Fluoroacetyl-CoA TE
3kuv, 3kuw, 3kvi – ScTE (mutant) + acetate derivative – Streptomyces cattleya
3kv7, 3kv8, 3p2r, 3p2s – ScTE + acetate derivative
3kvu – ScTE + acetyl-CoA
3kvz, 3kw1 – ScTE + FAcOPan
3kx7, 3fx8, 3p2q – ScTE
3p3f – ScTE (mutant)
3p3i - ScTE (mutant) + acetate derivative + CoA
Ubiquitin TE
USP 2
2zfy – hUSP – human
2hd5, 3nhe – hUSP + Ub
1tff – hUSP (mutant)
2ibi – hUSP (mutant) + Ub
USP 3
2qiy – USP + UBP-associated protein – yeast
USP 5
3ihp – hUSP + Ub
USP 7
2ylm, 2f1z – hUSP
2kvr – hUSP UBL domain - NMR
1nb8 – hUSP catalytic domain
1yze – hUSP N terminal domain
2f1w – hUSP TRAF-like domain
2f1x – hUSP TRAF-like domain + p53 peptide
2foj, 2foo – hUSP N terminal domain + p53 peptide
2f1y – hUSP TRAF-like domain + MDM2 peptide
2fop – hUSP N terminal domain + MDM2 peptide
1nbf – hUSP catalytic domain + ubiquitin aldehyde
1yy6 – hUSP N terminal domain + Epstein-Barr nuclear antigen
3mqr, 3mqs – hUSP + peptide
2xxn – hUSP + VIRF-4
4jjq – hUSP (mutant) + E2
USP 8
2a9u – hUSP N terminal domain
2gfo – hUSP catalytic domain
2gwf – hUSP rhodanese domain + ring finger protein
3mhh, 3m99, 4fip, 4fjc, 4fk5 – hUSP + SUS1 + SAGA-associated factors 11, 73
3mhs – hUSP + SUS1 + SAGA-associated factors 11, 73 + Ub
3n3k – hUSP + Ub inhibitor
USP 15
3lmn – hUSP DUSP domain
USP 16
2i50 – hUSP zinc finger domain - NMR
USP 21
3i3t – hUSP + Ub
3mtn – hUSP + Ub inhibitor
USP 28
2lva – hUSP N terminal - NMR
USP 33
2uzg – hUSP zinc finger domain - NMR
USP 37
3ihr – hUSP (mutant)
3a7s – hUSP catalytic domain (mutant)
USP Cyld
2vhf – hUSP
USP L1
3irt – hUSP (mutant)
2len – hUSP (mutant) - NMR
3ifw, 3kvf, 3kw5 – hUSP (mutant) + Ub
4dm9 – hUSP + peptide inhibitor
USP L5
3ris – hUSP catalytic domain
3rii – hUSP catalytic domain (mutant)
3tb3 – hUSP UCH domain (mutant)
USP ZranB1
3zrh – hUSP
USP OTUB1
3von – hUSP + E2
4ddg, 4ddi – hUSP + Ub
4ddi – hUSP (mutant) + Ub
4dhz – hUSP + E2 + Ub
4dhj – nUSP + E2 + Ub - nematode
4dhi – nUSP + E2
3znh – USP + Ub – Crimean-Congo hemorrhagic fever virus
RedJ TE
3qmv, 3qmw – TE – Streptomyces coelicolor
2av9 – TE – Pseudomonas aeruginosa
