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4lrg

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[[Category: Pardo, E.]]
[[Category: Pardo, E.]]
[[Category: Poy, F.]]
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[[Category: Ravichandran, S.]]
[[Category: Sandy, P.]]
[[Category: Sandy, P.]]
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[[Category: Sankaranarayanan, R.]]
 
[[Category: Sims, R.]]
[[Category: Sims, R.]]
[[Category: Taylor, A.]]
[[Category: Taylor, A.]]

Revision as of 06:33, 14 August 2013

Template:STRUCTURE 4lrg

Contents

Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4lrg is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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OCA

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