User:Alice Harmon/Sandbox 1
From Proteopedia
| Line 2: | Line 2: | ||
<Structure load='1ATP' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='1ATP' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
| - | <scene name='55/555705/Subdomaini/1'>Subdomain I</scene> | + | <scene name='55/555705/Subdomaini/1'>Subdomain I</scene> contains the glycine rich ATP-binding loop with the motif GxGxxG. |
| - | <scene name='55/555705/Subdomainii/1'>Subdomain II</scene> | + | <scene name='55/555705/Subdomainii/1'>Subdomain II</scene> contains the invariant lysine that couples the phosphates of ATP to the helix in subdomain III. |
| - | <scene name='55/555705/Subdomainiii/1'>Subdomain III</scene> | + | <scene name='55/555705/Subdomainiii/1'>Subdomain III</scene> connects to many parts of the kinase and it's orientation is critical for activity. In the active state its invariant glutamate forms a salt bridge with the invariant lysine of subdomain II. |
<scene name='55/555705/Subdomainiv/1'>Subdomain IV</scene> | <scene name='55/555705/Subdomainiv/1'>Subdomain IV</scene> | ||
| Line 12: | Line 12: | ||
<scene name='55/555705/Subdomainv/1'>Subdomain V</scene> | <scene name='55/555705/Subdomainv/1'>Subdomain V</scene> | ||
| - | <scene name='55/555705/Subdomainvia/1'>Subdomain VIa</scene> | + | <scene name='55/555705/Subdomainvia/1'>Subdomain VIa</scene> contains the catalytic loop. |
| - | <scene name='55/555705/Subdomainvib/1'>Subdomain VIb</scene> | + | <scene name='55/555705/Subdomainvib/1'>Subdomain VIb</scene> contains the Mg-binding loop with the DFG motif, the activation loop, the P+1 loop, and the APE motif. |
<scene name='55/555705/Subdomainvii/1'>Subdomain VII</scene> | <scene name='55/555705/Subdomainvii/1'>Subdomain VII</scene> | ||
| - | <scene name='55/555705/Subdomainviii/1'>Subdomain VIII</scene> | + | <scene name='55/555705/Subdomainviii/1'>Subdomain VIII</scene> contains the APE motif. The glutamate in this motif forms a salt bridge with an arginine in in Subdomain X1, which is critical for forming the stable kinase core. |
<scene name='55/555705/Subdomainix/1'>Subdomain IX</scene> | <scene name='55/555705/Subdomainix/1'>Subdomain IX</scene> | ||
| - | <scene name='55/555705/Subdomainx/1'>Subdomain X</scene> | + | <scene name='55/555705/Subdomainx/1'>Subdomain X</scene> and <scene name='55/555705/Subdomainxi/1'>Subdomain XI</scene> bind substrate proteins and forms the kinase core. |
| - | + | ||
| - | <scene name='55/555705/Subdomainxi/1'>Subdomain XI</scene> | + | |
Revision as of 15:06, 16 August 2013
Protein Kinase
|
contains the glycine rich ATP-binding loop with the motif GxGxxG.
contains the invariant lysine that couples the phosphates of ATP to the helix in subdomain III.
connects to many parts of the kinase and it's orientation is critical for activity. In the active state its invariant glutamate forms a salt bridge with the invariant lysine of subdomain II.
contains the catalytic loop.
contains the Mg-binding loop with the DFG motif, the activation loop, the P+1 loop, and the APE motif.
contains the APE motif. The glutamate in this motif forms a salt bridge with an arginine in in Subdomain X1, which is critical for forming the stable kinase core.
and bind substrate proteins and forms the kinase core.
