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4jb8

From Proteopedia

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m (Protected "4jb8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4jb8| PDB=4jb8 | SCENE= }}
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===Caspase-7 in Complex with DARPin C7_16===
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{{ABSTRACT_PUBMED_23868333}}
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The entry 4jb8 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
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Authors: Fluetsch, A., Seeger, M.A., Gruetter, M.G.
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==About this Structure==
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[[4jb8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JB8 OCA].
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Description: Caspase-7 in Complex with DARPin C7_16
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==Reference==
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<ref group="xtra">PMID:023868333</ref><references group="xtra"/><references/>
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[[Category: Caspase-7]]
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[[Category: Homo sapiens]]
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[[Category: Synthetic construct]]
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[[Category: Fluetsch, A.]]
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[[Category: Gruetter, M G.]]
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[[Category: Seeger, M A.]]
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[[Category: Complex structure]]
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[[Category: Hydrolase-de novo protein complex]]
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[[Category: Selected darpin c7_16]]

Revision as of 08:20, 21 August 2013

Template:STRUCTURE 4jb8

Contents

Caspase-7 in Complex with DARPin C7_16

Template:ABSTRACT PUBMED 23868333

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4jb8 is a 3 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA.

Reference

  • Seeger MA, Zbinden R, Flutsch A, Gutte PG, Engeler S, Roschitzki-Voser H, Grutter MG. Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci. 2013 Jul 19. doi: 10.1002/pro.2312. PMID:23868333 doi:10.1002/pro.2312

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OCA

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