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4k6e

From Proteopedia

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m (Protected "4k6e" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4k6e| PDB=4k6e | SCENE= }}
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===Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg===
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{{ABSTRACT_PUBMED_23911090}}
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The entry 4k6e is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/DCP2_YEAST DCP2_YEAST]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:10508173</ref> <ref>PMID:11139489</ref> <ref>PMID:11741542</ref> <ref>PMID:12554866</ref>
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Authors: Aglietti, R.A., Floor, S.N., Gross, J.D.
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==About this Structure==
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[[4k6e]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6E OCA].
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Description: Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg
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==Reference==
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<ref group="xtra">PMID:023911090</ref><references group="xtra"/><references/>
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[[Category: Saccharomyces cerevisiae s288c]]
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[[Category: Aglietti, R A.]]
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[[Category: Floor, S N.]]
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[[Category: Gross, J D.]]
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[[Category: Hydrolase]]
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[[Category: Mrna decapping]]
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[[Category: Nudix]]
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[[Category: Nudix hydrolase]]

Revision as of 08:26, 21 August 2013

Template:STRUCTURE 4k6e

Contents

Crystal structure of Saccharomyces cerevisiae Dcp2 Nudix domain in complex with Mg

Template:ABSTRACT PUBMED 23911090

Function

[DCP2_YEAST] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.[1] [2] [3] [4]

About this Structure

4k6e is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

  • Aglietti RA, Floor SN, McClendon CL, Jacobson MP, Gross JD. Active Site Conformational Dynamics Are Coupled to Catalysis in the mRNA Decapping Enzyme Dcp2. Structure. 2013 Jul 31. pii: S0969-2126(13)00245-1. doi:, 10.1016/j.str.2013.06.021. PMID:23911090 doi:10.1016/j.str.2013.06.021
  1. ↑ Dunckley T, Parker R. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J. 1999 Oct 1;18(19):5411-22. PMID:10508173 doi:10.1093/emboj/18.19.5411
  2. ↑ Dunckley T, Tucker M, Parker R. Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics. 2001 Jan;157(1):27-37. PMID:11139489
  3. ↑ Tharun S, Parker R. Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs. Mol Cell. 2001 Nov;8(5):1075-83. PMID:11741542
  4. ↑ Steiger M, Carr-Schmid A, Schwartz DC, Kiledjian M, Parker R. Analysis of recombinant yeast decapping enzyme. RNA. 2003 Feb;9(2):231-8. PMID:12554866

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