4bsv
From Proteopedia
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| - | + | {{STRUCTURE_4bsv| PDB=4bsv | SCENE= }} | |
| + | ===Heterodimeric Fc Antibody Azymetric Variant 1=== | ||
| - | + | ==Disease== | |
| + | [[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4. | ||
| - | + | ==About this Structure== | |
| - | + | [[4bsv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BSV OCA]. | |
| - | + | [[Category: Homo sapiens]] | |
| + | [[Category: Angelo, I E.P D.]] | ||
| + | [[Category: Boulanger, M J.]] | ||
| + | [[Category: Cabrera, E E.]] | ||
| + | [[Category: Dixit, S B.]] | ||
| + | [[Category: Lario, P I.]] | ||
| + | [[Category: Poon, D K.Y.]] | ||
| + | [[Category: Spreter, T.]] | ||
| + | [[Category: Suits, M D.L.]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: Antibody engineering]] | ||
| + | [[Category: Bispecific]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Scaffold]] | ||
| + | [[Category: Zymeworks inc.]] | ||
Revision as of 08:31, 21 August 2013
Heterodimeric Fc Antibody Azymetric Variant 1
Disease
[IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
About this Structure
4bsv is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
