4htz

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'''Unreleased structure'''
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{{STRUCTURE_4htz| PDB=4htz | SCENE= }}
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===Crystal structure of PDE2 catalytic domain in space group P1===
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{{ABSTRACT_PUBMED_23899287}}
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The entry 4htz is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PDE2A_HUMAN PDE2A_HUMAN]] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.<ref>PMID:15938621</ref> <ref>PMID:19828435</ref>
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Authors: Zhu, J., Huang, Q.
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==About this Structure==
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[[4htz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HTZ OCA].
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Description: Crystal structure of PDE2 catalytic domain in space group P1
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==Reference==
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<ref group="xtra">PMID:023899287</ref><references group="xtra"/><references/>
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Huang, Q.]]
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[[Category: Zhu, J.]]
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[[Category: Hydrolase]]

Revision as of 07:25, 28 August 2013

Template:STRUCTURE 4htz

Contents

Crystal structure of PDE2 catalytic domain in space group P1

Template:ABSTRACT PUBMED 23899287

Function

[PDE2A_HUMAN] Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.[1] [2]

About this Structure

4htz is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Zhu J, Yang Q, Dai D, Huang Q. X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity. J Am Chem Soc. 2013 Aug 14;135(32):11708-11. doi: 10.1021/ja404449g. Epub 2013, Aug 2. PMID:23899287 doi:10.1021/ja404449g
  1. ↑ Iffland A, Kohls D, Low S, Luan J, Zhang Y, Kothe M, Cao Q, Kamath AV, Ding YH, Ellenberger T. Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. Biochemistry. 2005 Jun 14;44(23):8312-25. PMID:15938621 doi:10.1021/bi047313h
  2. ↑ Pandit J, Forman MD, Fennell KF, Dillman KS, Menniti FS. Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct. Proc Natl Acad Sci U S A. 2009 Oct 14. PMID:19828435

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