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1w1i
From Proteopedia
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[[Category: serine protease]] | [[Category: serine protease]] | ||
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Revision as of 14:17, 30 October 2007
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CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE
Overview
Dipeptidyl-peptidase IV (DPPIV or CD26) is a homodimeric type II membrane, glycoprotein in which the two monomers are subdivided into a, beta-propeller domain and an alpha/beta-hydrolase domain. As dipeptidase, DPPIV modulates the activity of various biologically important peptides, and, in addition, DPPIV acts as a receptor for adenosine deaminase (ADA), thereby mediating co-stimulatory signals in T-lymphocytes. The 3.0-A, resolution crystal structure of the complex formed between human DPPIV and, bovine ADA presented here shows that each beta-propeller domain of the, DPPIV dimer binds one ADA. At the binding interface, two hydrophobic loops, protruding from the beta-propeller domain of DPPIV interact with two, hydrophilic and heavily charged alpha-helices of ADA, giving rise to the, ... [(full description)]
About this Structure
1W1I is a [Protein complex] structure of sequences from [Bos taurus] and [Homo sapiens] with NAG, NDG and ZN as [ligands]. Active as [Dipeptidyl-peptidase IV], with EC number [3.4.14.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface., Weihofen WA, Liu J, Reutter W, Saenger W, Fan H, J Biol Chem. 2004 Oct 8;279(41):43330-5. Epub 2004 Jun 22. PMID:15213224
Page seeded by OCA on Tue Oct 30 16:21:44 2007
Categories: Bos taurus | Dipeptidyl-peptidase IV | Homo sapiens | Protein complex | Fan, H. | Liu, J. | Reutter, W. | Saenger, W. | Weihofen, W.A. | NAG | NDG | ZN | Ada | Adenosine deaminase | Alpha/beta-hydrolase fold | Aminopeptidase | Beta-propeller fold | Cd26 | Dipetidyl peptidase iv | Dppiv | Protein-protein complex | Serine protease
