4dhs
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4dhs| PDB=4dhs | SCENE= }} | {{STRUCTURE_4dhs| PDB=4dhs | SCENE= }} | ||
===Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening=== | ===Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening=== | ||
| + | {{ABSTRACT_PUBMED_23939230}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHS OCA]. | [[4dhs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DHS OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023939230</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Kohlbacher, O.]] | [[Category: Kohlbacher, O.]] | ||
Revision as of 08:54, 4 September 2013
Contents |
Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Template:ABSTRACT PUBMED 23939230
Function
[1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
About this Structure
4dhs is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Thiel P, Roglin L, Meissner N, Hennig S, Kohlbacher O, Ottmann C. Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions. Chem Commun (Camb). 2013 Aug 27;49(76):8468-70. doi: 10.1039/c3cc44612c. PMID:23939230 doi:10.1039/c3cc44612c
