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3gmd

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[[Image:3gmd.png|left|200px]]
 
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{{STRUCTURE_3gmd| PDB=3gmd | SCENE= }}
{{STRUCTURE_3gmd| PDB=3gmd | SCENE= }}
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===Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I===
===Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I===
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{{ABSTRACT_PUBMED_22901389}}
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==Function==
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[[http://www.uniprot.org/uniprot/DHI1_MOUSE DHI1_MOUSE]] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.
==About this Structure==
==About this Structure==
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==See Also==
==See Also==
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
*[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]]
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==Reference==
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<ref group="xtra">PMID:022901389</ref><references group="xtra"/><references/>
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: 11-beta-hydroxysteroid dehydrogenase]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]

Revision as of 08:57, 4 September 2013

Template:STRUCTURE 3gmd

Contents

Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I

Template:ABSTRACT PUBMED 22901389

Function

[DHI1_MOUSE] Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone.

About this Structure

3gmd is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

See Also

Reference

  • Valeur E, Christmann-Franck S, Lepifre F, Carniato D, Cravo D, Charon C, Bozec S, Musil D, Hillertz P, Doare L, Schmidlin F, Lecomte M, Schultz M, Roche D. Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11beta-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5909-14. doi:, 10.1016/j.bmcl.2012.07.070. Epub 2012 Jul 31. PMID:22901389 doi:10.1016/j.bmcl.2012.07.070

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OCA

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