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4jvm

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4jvm| PDB=4jvm | SCENE= }}
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===Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and brominated flame retardant TBBPA (tetrabromobisphenol A)===
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{{ABSTRACT_PUBMED_23959441}}
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The entry 4jvm is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ST1E1_HUMAN ST1E1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.<ref>PMID:11884392</ref>
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Authors: Gosavi, R.A., Knudsen, G.A., Birnbaum, L.S., Pedersen, L.C.
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==About this Structure==
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[[4jvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVM OCA].
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Description: Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and brominated flame retardant TBBPA (tetrabromobisphenol A)
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==Reference==
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<ref group="xtra">PMID:023959441</ref><references group="xtra"/><references/>
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[[Category: Estrone sulfotransferase]]
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[[Category: Homo sapiens]]
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[[Category: Birnbaum, L S.]]
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[[Category: Gosavi, R A.]]
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[[Category: Knudsen, G A.]]
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[[Category: Pedersen, L C.]]
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[[Category: Cytosolic sulfotransferase]]
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[[Category: Transferase]]

Revision as of 10:47, 4 September 2013

Template:STRUCTURE 4jvm

Contents

Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and brominated flame retardant TBBPA (tetrabromobisphenol A)

Template:ABSTRACT PUBMED 23959441

Function

[ST1E1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.[1]

About this Structure

4jvm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Gosavi RA, Knudsen GA, Birnbaum LS, Pedersen LC. Mimicking of Estradiol Binding by Flame Retardants and Their Metabolites: A Crystallographic Analysis. Environ Health Perspect. 2013 Aug 19. PMID:23959441 doi:10.1289/ehp.1306902
  1. ↑ Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. J Biol Chem. 2002 May 17;277(20):17928-32. Epub 2002 Mar 7. PMID:11884392 doi:http://dx.doi.org/10.1074/jbc.M111651200

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