4hq0

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'''Unreleased structure'''
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{{STRUCTURE_4hq0| PDB=4hq0 | SCENE= }}
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===Crystal Structure of mutant form of Caspase-7===
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{{ABSTRACT_PUBMED_23897474}}
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The entry 4hq0 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CASP7_HUMAN CASP7_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
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Authors: Lee, Y., Kang, H.J., Bae, K.-H., Kim, S.J., Chung, S.J.
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==About this Structure==
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[[4hq0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HQ0 OCA].
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Description: Crystal Structure of mutant form of Caspase-7
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==Reference==
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<ref group="xtra">PMID:023897474</ref><references group="xtra"/><references/>
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[[Category: Caspase-7]]
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[[Category: Homo sapiens]]
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[[Category: Bae, K H.]]
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[[Category: Chung, S J.]]
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[[Category: Kang, H J.]]
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[[Category: Kim, S J.]]
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[[Category: Lee, Y.]]
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[[Category: Hydrolase]]

Revision as of 05:18, 12 September 2013

Template:STRUCTURE 4hq0

Contents

Crystal Structure of mutant form of Caspase-7

Template:ABSTRACT PUBMED 23897474

Function

[CASP7_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

About this Structure

4hq0 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kang HJ, Lee YM, Bae KH, Kim SJ, Chung SJ. Structural asymmetry of procaspase-7 bound to a specific inhibitor. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1514-21. doi:, 10.1107/S0907444913010196. Epub 2013 Jul 18. PMID:23897474 doi:10.1107/S0907444913010196

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OCA

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