2ly2

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'''Unreleased structure'''
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{{STRUCTURE_2ly2| PDB=2ly2 | SCENE= }}
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===NMR structure of the second and third lotus domains of tudor domain-containing protein 7 (NMR ensemble overlay for Lotus #3)===
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The entry 2ly2 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TDRD7_MOUSE TDRD7_MOUSE]] Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.<ref>PMID:21436445</ref>
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Authors: Cui, G., Botuyan, M., Mer, G.
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==About this Structure==
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[[2ly2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LY2 OCA].
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Description:
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Botuyan, M.]]
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[[Category: Cui, G.]]
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[[Category: Mer, G.]]
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[[Category: Germinal granule]]
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[[Category: Lotus domain]]
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[[Category: Ost-hth domain]]
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[[Category: Rna binding domain]]
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[[Category: Rna binding protein]]
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[[Category: Tdrd7]]

Revision as of 05:27, 12 September 2013

Template:STRUCTURE 2ly2

Contents

NMR structure of the second and third lotus domains of tudor domain-containing protein 7 (NMR ensemble overlay for Lotus #3)

Function

[TDRD7_MOUSE] Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.[1]

About this Structure

2ly2 is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

Reference

  1. ↑ Lachke SA, Alkuraya FS, Kneeland SC, Ohn T, Aboukhalil A, Howell GR, Saadi I, Cavallesco R, Yue Y, Tsai AC, Nair KS, Cosma MI, Smith RS, Hodges E, Alfadhli SM, Al-Hajeri A, Shamseldin HE, Behbehani A, Hannon GJ, Bulyk ML, Drack AV, Anderson PJ, John SW, Maas RL. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011 Mar 25;331(6024):1571-6. doi: 10.1126/science.1195970. PMID:21436445 doi:10.1126/science.1195970

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OCA

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