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3ong

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[[Image:3ong.png|left|200px]]
 
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{{STRUCTURE_3ong| PDB=3ong | SCENE= }}
{{STRUCTURE_3ong| PDB=3ong | SCENE= }}
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===Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in Sumo pathways===
===Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in Sumo pathways===
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{{ABSTRACT_PUBMED_21209884}}
{{ABSTRACT_PUBMED_21209884}}
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==Function==
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[[http://www.uniprot.org/uniprot/UBA2_YEAST UBA2_YEAST]] The dimeric enzyme acts as a SMT3 E1 ligase. It mediates ATP-dependent activation of SMT3 and formation of a thioester with a conserved cysteine residue on AOS1. [[http://www.uniprot.org/uniprot/UBC9_YEAST UBC9_YEAST]] E2 ubiquitin-like--protein ligase mediating SUMO/Smt3 attachment to septins and PCNA. Seems to be involved in degradation of S- (CLB5) and M-phase cyclins (CLB2).<ref>PMID:9341106</ref> <ref>PMID:11572779</ref>
==About this Structure==
==About this Structure==
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==See Also==
==See Also==
*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
*[[SUMO conjugating enzyme Ubc9|SUMO conjugating enzyme Ubc9]]
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*[[Ubiquitin activating enzyme|Ubiquitin activating enzyme]]
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==Reference==
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<ref group="xtra">PMID:021209884</ref><references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Huang, D T.]]
[[Category: Huang, D T.]]

Revision as of 02:45, 20 September 2013

Template:STRUCTURE 3ong

Contents

Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in Sumo pathways

Template:ABSTRACT PUBMED 21209884

Function

[UBA2_YEAST] The dimeric enzyme acts as a SMT3 E1 ligase. It mediates ATP-dependent activation of SMT3 and formation of a thioester with a conserved cysteine residue on AOS1. [UBC9_YEAST] E2 ubiquitin-like--protein ligase mediating SUMO/Smt3 attachment to septins and PCNA. Seems to be involved in degradation of S- (CLB5) and M-phase cyclins (CLB2).[1] [2]

About this Structure

3ong is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

See Also

Reference

  • Wang J, Taherbhoy AM, Hunt HW, Seyedin SN, Miller DW, Miller DJ, Huang DT, Schulman BA. Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways. PLoS One. 2010 Dec 30;5(12):e15805. PMID:21209884 doi:10.1371/journal.pone.0015805
  1. ↑ Johnson ES, Blobel G. Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3p. J Biol Chem. 1997 Oct 24;272(43):26799-802. PMID:9341106
  2. ↑ Johnson ES, Gupta AA. An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell. 2001 Sep 21;106(6):735-44. PMID:11572779

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