4jw3

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m (Protected "4jw3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4jw3| PDB=4jw3 | SCENE= }}
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===Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)===
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{{ABSTRACT_PUBMED_24014183}}
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The entry 4jw3 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NCZS_STRML NCZS_STRML]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
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Authors: Guellouz, A., Valerio-Lepiniec, M., Urvoas, A., Chevrel, A., Graille, M., Fourati-Kammoun, Z., Desmadril, M., van Tilbeurgh, H., Minard, P.
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==About this Structure==
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[[4jw3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Gekko_coi Gekko coi] and [http://en.wikipedia.org/wiki/Streptomyces_malayensis Streptomyces malayensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JW3 OCA].
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Description: Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)
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==Reference==
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<ref group="xtra">PMID:024014183</ref><references group="xtra"/><references/>
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[[Category: Gekko coi]]
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[[Category: Streptomyces malayensis]]
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[[Category: Chevrel, A.]]
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[[Category: Desmadril, M.]]
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[[Category: Fourati-Kammoun, Z.]]
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[[Category: Graille, M.]]
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[[Category: Guellouz, A.]]
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[[Category: Minard, P.]]
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[[Category: Tilbeurgh, H van.]]
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[[Category: Urvoas, A.]]
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[[Category: Valerio-Lepiniec, M.]]
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[[Category: Alpha-helical protein]]
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[[Category: Dna binding protein-de novo protein complex]]
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[[Category: Ncs 3tes24 variant]]
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[[Category: Protein engineered to interact with protein of interest]]

Revision as of 08:10, 29 September 2013

Template:STRUCTURE 4jw3

Contents

Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)

Template:ABSTRACT PUBMED 24014183

Function

[NCZS_STRML] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.

About this Structure

4jw3 is a 4 chain structure with sequence from Gekko coi and Streptomyces malayensis. Full crystallographic information is available from OCA.

Reference

  • Guellouz A, Valerio-Lepiniec M, Urvoas A, Chevrel A, Graille M, Fourati-Kammoun Z, Desmadril M, van Tilbeurgh H, Minard P. Selection of Specific Protein Binders for Pre-Defined Targets from an Optimized Library of Artificial Helicoidal Repeat Proteins (alphaRep). PLoS One. 2013 Aug 27;8(8):e71512. doi: 10.1371/journal.pone.0071512. PMID:24014183 doi:10.1371/journal.pone.0071512

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