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4l00
From Proteopedia
(Difference between revisions)
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{{STRUCTURE_4l00| PDB=4l00 | SCENE= }} | {{STRUCTURE_4l00| PDB=4l00 | SCENE= }} | ||
===Crystal structure of the apo Jak1 pseudokinase domain=== | ===Crystal structure of the apo Jak1 pseudokinase domain=== | ||
| + | {{ABSTRACT_PUBMED_24013208}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4l00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L00 OCA]. | [[4l00]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L00 OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:024013208</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
Revision as of 05:59, 2 October 2013
Contents |
Crystal structure of the apo Jak1 pseudokinase domain
Template:ABSTRACT PUBMED 24013208
Function
[JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
About this Structure
4l00 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Toms AV, Deshpande A, McNally R, Jeong Y, Rogers JM, Kim CU, Gruner SM, Ficarro SB, Marto JA, Sattler M, Griffin JD, Eck MJ. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Mol Biol. 2013 Sep 8. doi: 10.1038/nsmb.2673. PMID:24013208 doi:10.1038/nsmb.2673
