This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4jby
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:4jby.jpg|left|200px]] | ||
| - | |||
{{STRUCTURE_4jby| PDB=4jby | SCENE= }} | {{STRUCTURE_4jby| PDB=4jby | SCENE= }} | ||
| - | |||
===Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78=== | ===Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78=== | ||
| - | |||
{{ABSTRACT_PUBMED_21623543}} | {{ABSTRACT_PUBMED_21623543}} | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity). | ||
==About this Structure== | ==About this Structure== | ||
[[4jby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBY OCA]. | [[4jby]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBY OCA]. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Thymidine kinase|Thymidine kinase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:021623543</ref><references group="xtra"/> | + | <ref group="xtra">PMID:021623543</ref><references group="xtra"/><references/> |
[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
[[Category: Novakovic, I.]] | [[Category: Novakovic, I.]] | ||
| Line 18: | Line 20: | ||
[[Category: Raic-Malic, S.]] | [[Category: Raic-Malic, S.]] | ||
[[Category: Scapozza, L.]] | [[Category: Scapozza, L.]] | ||
| + | [[Category: Westermaier, Y.]] | ||
[[Category: Atp binding]] | [[Category: Atp binding]] | ||
[[Category: Dna synthesis]] | [[Category: Dna synthesis]] | ||
Revision as of 06:16, 2 October 2013
Contents |
Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with F-SK78
Template:ABSTRACT PUBMED 21623543
Function
[KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
About this Structure
4jby is a 2 chain structure with sequence from Herpes simplex virus (type 1 / strain 17). Full crystallographic information is available from OCA.
See Also
Reference
- Martic M, Pernot L, Westermaier Y, Perozzo R, Kraljevic TG, Kristafor S, Raic-Malic S, Scapozza L, Ametamey S. Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids. 2011 Apr;30(4):293-315. PMID:21623543 doi:10.1080/15257770.2011.581258
