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4kbm
From Proteopedia
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| - | + | {{STRUCTURE_4kbm| PDB=4kbm | SCENE= }} | |
| + | ===Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/RPOB_MYCTU RPOB_MYCTU]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321] [[http://www.uniprot.org/uniprot/CARD_MYCTU CARD_MYCTU]] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.<ref>PMID:19596241</ref> <ref>PMID:22904282</ref> | ||
| - | + | ==About this Structure== | |
| + | [[4kbm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBM OCA]. | ||
| - | + | ==Reference== | |
| + | <references group="xtra"/><references/> | ||
| + | [[Category: DNA-directed RNA polymerase]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
| + | [[Category: Gulten, G.]] | ||
| + | [[Category: Sacchettini, J C.]] | ||
| + | [[Category: TBSGC, TB Structural Genomics Consortium.]] | ||
| + | [[Category: Card]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: Dna-dependent rna polymerase]] | ||
| + | [[Category: Protein-protein complex]] | ||
| + | [[Category: Sigma factor]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Tb structural genomics consortium]] | ||
| + | [[Category: Tbsgc]] | ||
| + | [[Category: Transcription regulator]] | ||
| + | [[Category: Transferase-transcription complex]] | ||
| + | [[Category: Tudor]] | ||
Revision as of 07:35, 2 October 2013
Contents |
Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex
Function
[RPOB_MYCTU] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.[HAMAP-Rule:MF_01321] [CARD_MYCTU] Controls rRNA transcription by binding to the RNA polymerase (RNAP). Required for replication and persistence during infection of mice.[1] [2]
About this Structure
4kbm is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- ↑ Stallings CL, Stephanou NC, Chu L, Hochschild A, Nickels BE, Glickman MS. CarD is an essential regulator of rRNA transcription required for Mycobacterium tuberculosis persistence. Cell. 2009 Jul 10;138(1):146-59. doi: 10.1016/j.cell.2009.04.041. PMID:19596241 doi:10.1016/j.cell.2009.04.041
- ↑ Weiss LA, Harrison PG, Nickels BE, Glickman MS, Campbell EA, Darst SA, Stallings CL. Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis. J Bacteriol. 2012 Oct;194(20):5621-31. Epub 2012 Aug 17. PMID:22904282 doi:10.1128/JB.00879-12
Categories: DNA-directed RNA polymerase | Mycobacterium tuberculosis | Gulten, G. | Sacchettini, J C. | TBSGC, TB Structural Genomics Consortium. | Card | Dna | Dna-dependent rna polymerase | Protein-protein complex | Sigma factor | Structural genomic | Tb structural genomics consortium | Tbsgc | Transcription regulator | Transferase-transcription complex | Tudor
