2oq1
From Proteopedia
(New page: 200px<br /> <applet load="2oq1" size="450" color="white" frame="true" align="right" spinBox="true" caption="2oq1, resolution 1.9Å" /> '''Tandem SH2 domains o...) |
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| - | [[Image:2oq1.gif|left|200px]]<br /> | + | [[Image:2oq1.gif|left|200px]]<br /><applet load="2oq1" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="2oq1" size=" | + | |
caption="2oq1, resolution 1.9Å" /> | caption="2oq1, resolution 1.9Å" /> | ||
'''Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide'''<br /> | '''Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The crystal structure of the tandem SH2 domains of human ZAP-70 in complex | + | The crystal structure of the tandem SH2 domains of human ZAP-70 in complex with a peptide derived from the zeta-subunit of the T-cell receptor reveals an unanticipated interaction between the two domains. A coiled coil of alpha-helices connects the two SH2 domains, producing an interface that constitutes one of the two critical phosphotyrosine binding sites. These and other unique features provide the molecular basis for highly selective association of ZAP-70 with the T-cell receptor. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2OQ1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PB as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] Full crystallographic information is available from [http:// | + | 2OQ1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PB:'>PB</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQ1 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Green, J.]] | [[Category: Green, J.]] | ||
| - | [[Category: Hatada, M | + | [[Category: Hatada, M H.]] |
| - | [[Category: Laird, E | + | [[Category: Laird, E R.]] |
[[Category: Morgenstern, J.]] | [[Category: Morgenstern, J.]] | ||
| - | [[Category: Ram, M | + | [[Category: Ram, M K.]] |
[[Category: PB]] | [[Category: PB]] | ||
[[Category: tandem sh2 domains]] | [[Category: tandem sh2 domains]] | ||
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[[Category: zap-70]] | [[Category: zap-70]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:21:16 2008'' |
Revision as of 16:21, 21 February 2008
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Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide
Contents |
Overview
The crystal structure of the tandem SH2 domains of human ZAP-70 in complex with a peptide derived from the zeta-subunit of the T-cell receptor reveals an unanticipated interaction between the two domains. A coiled coil of alpha-helices connects the two SH2 domains, producing an interface that constitutes one of the two critical phosphotyrosine binding sites. These and other unique features provide the molecular basis for highly selective association of ZAP-70 with the T-cell receptor.
Disease
Known diseases associated with this structure: Immunodeficiency due to defect in CD3-zeta OMIM:[186780], Selective T-cell defect OMIM:[176947]
About this Structure
2OQ1 is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as Non-specific protein-tyrosine kinase, with EC number 2.7.10.2 Full crystallographic information is available from OCA.
Reference
Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor., Hatada MH, Lu X, Laird ER, Green J, Morgenstern JP, Lou M, Marr CS, Phillips TB, Ram MK, Theriault K, et al., Nature. 1995 Sep 7;377(6544):32-8. PMID:7659156
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