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4c57

From Proteopedia

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m (Protected "4c57" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4c57| PDB=4c57 | SCENE= }}
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===Structure of GAK kinase in complex with a nanobody===
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The entry 4c57 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/GAK_HUMAN GAK_HUMAN]] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.<ref>PMID:10625686</ref>
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Authors: Chaikuad, A., Keates, T., Krojer, T., Allerston, C.K., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Muller-Knapp, S.
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==About this Structure==
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[[4c57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C57 OCA].
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Description: Structure of GAK kinase in complex with a nanobody
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Allerston, C K.]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Chaikuad, A.]]
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[[Category: Delft, F von.]]
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[[Category: Edwards, A M.]]
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[[Category: Keates, T.]]
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[[Category: Knapp, S.]]
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[[Category: Krojer, T.]]
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[[Category: Muller-Knapp, S.]]
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[[Category: Activation]]
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[[Category: Conformational plasticity]]
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[[Category: Kinase]]
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[[Category: Transferase]]

Revision as of 06:35, 10 October 2013

Template:STRUCTURE 4c57

Contents

Structure of GAK kinase in complex with a nanobody

Function

[GAK_HUMAN] Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.[1]

About this Structure

4c57 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. ↑ Greener T, Zhao X, Nojima H, Eisenberg E, Greene LE. Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells. J Biol Chem. 2000 Jan 14;275(2):1365-70. PMID:10625686

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OCA

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