3fpu

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[[Image:3fpu.png|left|200px]]
 
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{{STRUCTURE_3fpu| PDB=3fpu | SCENE= }}
{{STRUCTURE_3fpu| PDB=3fpu | SCENE= }}
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===The crystallographic structure of the Complex between Evasin-1 and CCL3===
===The crystallographic structure of the Complex between Evasin-1 and CCL3===
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{{ABSTRACT_PUBMED_20041127}}
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{{ABSTRACT_PUBMED_20041127}}
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==Function==
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[[http://www.uniprot.org/uniprot/EVA1_RHISA EVA1_RHISA]] Shows chemokine neutralizing activity. Binds to chemokines CCL3, CCL4 and CCL18.<ref>PMID:17640866</ref> <ref>PMID:18678732</ref> [[http://www.uniprot.org/uniprot/CCL3_HUMAN CCL3_HUMAN]] Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).<ref>PMID:8525373</ref>
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:020041127</ref><ref group="xtra">PMID:017640866</ref><ref group="xtra">PMID:018678732</ref><references group="xtra"/>
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<ref group="xtra">PMID:020041127</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Rhipicephalus sanguineus]]
[[Category: Rhipicephalus sanguineus]]

Revision as of 06:46, 16 October 2013

Template:STRUCTURE 3fpu

Contents

The crystallographic structure of the Complex between Evasin-1 and CCL3

Template:ABSTRACT PUBMED 20041127

Function

[EVA1_RHISA] Shows chemokine neutralizing activity. Binds to chemokines CCL3, CCL4 and CCL18.[1] [2] [CCL3_HUMAN] Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).[3]

About this Structure

3fpu is a 2 chain structure with sequence from Homo sapiens and Rhipicephalus sanguineus. Full crystallographic information is available from OCA.

Reference

  • Dias JM, Losberger C, Deruaz M, Power CA, Proudfoot AE, Shaw JP. Structural basis of chemokine sequestration by a tick chemokine binding protein: the crystal structure of the complex between Evasin-1 and CCL3. PLoS One. 2009 Dec 30;4(12):e8514. PMID:20041127 doi:10.1371/journal.pone.0008514
  1. ↑ Frauenschuh A, Power CA, Deruaz M, Ferreira BR, Silva JS, Teixeira MM, Dias JM, Martin T, Wells TN, Proudfoot AE. Molecular cloning and characterization of a highly selective chemokine-binding protein from the tick Rhipicephalus sanguineus. J Biol Chem. 2007 Sep 14;282(37):27250-8. Epub 2007 Jul 19. PMID:17640866 doi:10.1074/jbc.M704706200
  2. ↑ Deruaz M, Frauenschuh A, Alessandri AL, Dias JM, Coelho FM, Russo RC, Ferreira BR, Graham GJ, Shaw JP, Wells TN, Teixeira MM, Power CA, Proudfoot AE. Ticks produce highly selective chemokine binding proteins with antiinflammatory activity. J Exp Med. 2008 Sep 1;205(9):2019-31. Epub 2008 Aug 4. PMID:18678732 doi:10.1084/jem.20072689
  3. ↑ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995 Dec 15;270(5243):1811-5. PMID:8525373

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