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The <scene name='56/563196/Interactions/1'>ligand FLC interacts</scene> with <scene name='56/563196/Interactions/2'>residues</scene> such as Arg (+ charge), Lys (+ charge), Thr (polar), Gly (nonpolar), and Asp (- charge).
The <scene name='56/563196/Interactions/1'>ligand FLC interacts</scene> with <scene name='56/563196/Interactions/2'>residues</scene> such as Arg (+ charge), Lys (+ charge), Thr (polar), Gly (nonpolar), and Asp (- charge).
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Catalytic residues
 
The 4IP7 form of pyruvate kinase does not contain catalytic residues according to PDBsum. However, <scene name='56/563196/3gqy/1'>3GQY</scene>, the activator-bound form, shows similar
The 4IP7 form of pyruvate kinase does not contain catalytic residues according to PDBsum. However, <scene name='56/563196/3gqy/1'>3GQY</scene>, the activator-bound form, shows similar
<scene name='56/563196/3gqy_ligand_interaction/2'>ligand interactions</scene> and does show its <scene name='56/563196/3gqy_active_site/2'>active site</scene> (in green).
<scene name='56/563196/3gqy_ligand_interaction/2'>ligand interactions</scene> and does show its <scene name='56/563196/3gqy_active_site/2'>active site</scene> (in green).

Revision as of 18:31, 18 October 2013

This Sandbox is Reserved from Oct 10, 2013, through May 20, 2014 for use in the course "CHEM 410 Biochemistry 1 and 2" taught by Hanna Tims at the Messiah College. This reservation includes Sandbox Reserved 780 through Sandbox Reserved 807.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

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pyruvate kinase

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Introduction

Pyruvate kinase (a transferase, PDB 4IP7) What's it do Research about it

Structure

Pyruvate kinase is a , meaning it has four identical . This enzyme contains both and .

It has three . consists of an alpha-beta-alpha 3-layer sandwich. consists of a parallel alpha-beta barrel. consists of an anti-parallel beta-barrel.

in the backbone show the interactions within the elements of secondary structure.

of the side chains is shown. Hydrophobic side chains are grey while hydrophilic side chains are purple. You can see that the hydrophobic residues are mostly on the interior, buried within the protein, while hydrophilic are on the outside. is in contact with most of the chain except the largely hydrophobic 3 beta barrel (shown in green). When looking at the quaternary , water is present over most of the exterior except the cavity in the middle and the outer barrels in 3 (green).

The with such as Arg (+ charge), Lys (+ charge), Thr (polar), Gly (nonpolar), and Asp (- charge).

The 4IP7 form of pyruvate kinase does not contain catalytic residues according to PDBsum. However, , the activator-bound form, shows similar and does show its (in green).

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