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4jeh
From Proteopedia
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{{STRUCTURE_4jeh| PDB=4jeh | SCENE= }} | {{STRUCTURE_4jeh| PDB=4jeh | SCENE= }} | ||
===Crystal Structure of Munc18a and Syntaxin1 lacking N-peptide complex=== | ===Crystal Structure of Munc18a and Syntaxin1 lacking N-peptide complex=== | ||
| + | {{ABSTRACT_PUBMED_23858467}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4jeh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEH OCA]. | [[4jeh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JEH OCA]. | ||
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| + | ==Reference== | ||
| + | <ref group="xtra">PMID:023858467</ref><references group="xtra"/><references/> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Burkhardt, P.]] | [[Category: Burkhardt, P.]] | ||
Revision as of 05:07, 23 October 2013
Contents |
Crystal Structure of Munc18a and Syntaxin1 lacking N-peptide complex
Template:ABSTRACT PUBMED 23858467
Function
[STXB1_RAT] May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. [STX1A_RAT] Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
About this Structure
4jeh is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Colbert KN, Hattendorf DA, Weiss TM, Burkhardt P, Fasshauer D, Weis WI. Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12637-42. doi:, 10.1073/pnas.1303753110. Epub 2013 Jul 15. PMID:23858467 doi:http://dx.doi.org/10.1073/pnas.1303753110
