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4m9s

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'''Unreleased structure'''
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{{STRUCTURE_4m9s| PDB=4m9s | SCENE= }}
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===crystal structure of CED-4 bound CED-3 fragment===
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{{ABSTRACT_PUBMED_24065769}}
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The entry 4m9s is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CED4_CAEEL CED4_CAEEL]] Isoform a plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Isoform b prevents PCD.<ref>PMID:1286611</ref> <ref>PMID:8706125</ref> <ref>PMID:9027313</ref> <ref>PMID:10688797</ref> <ref>PMID:15383288</ref>
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Authors: Huang, W.J., Jinag, T.Y., Choi, W.Y., Wang, J.W., Shi, Y.G.
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==About this Structure==
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[[4m9s]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M9S OCA].
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Description: crystal structure of CED-4 bound CED-3 fragment
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==Reference==
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<ref group="xtra">PMID:024065769</ref><references group="xtra"/><references/>
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[[Category: Caenorhabditis elegans]]
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[[Category: Choi, W Y.]]
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[[Category: Huang, W J.]]
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[[Category: Jinag, T Y.]]
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[[Category: Shi, Y G.]]
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[[Category: Wang, J W.]]
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[[Category: Apoptosis]]
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[[Category: Apoptosome]]
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[[Category: Ced-3]]

Revision as of 06:42, 23 October 2013

Template:STRUCTURE 4m9s

Contents

crystal structure of CED-4 bound CED-3 fragment

Template:ABSTRACT PUBMED 24065769

Function

[CED4_CAEEL] Isoform a plays a major role in programmed cell death (PCD, apoptosis). Egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Isoform b prevents PCD.[1] [2] [3] [4] [5]

About this Structure

4m9s is a 8 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

  • Huang W, Jiang T, Choi W, Qi S, Pang Y, Hu Q, Xu Y, Gong X, Jeffrey PD, Wang J, Shi Y. Mechanistic insights into CED-4-mediated activation of CED-3. Genes Dev. 2013 Sep 15;27(18):2039-48. doi: 10.1101/gad.224428.113. PMID:24065769 doi:http://dx.doi.org/10.1101/gad.224428.113
  1. ↑ Yuan J, Horvitz HR. The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development. 1992 Oct;116(2):309-20. PMID:1286611
  2. ↑ Shaham S, Horvitz HR. An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell. 1996 Jul 26;86(2):201-8. PMID:8706125
  3. ↑ Wu D, Wallen HD, Nunez G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science. 1997 Feb 21;275(5303):1126-9. PMID:9027313
  4. ↑ Chen F, Hersh BM, Conradt B, Zhou Z, Riemer D, Gruenbaum Y, Horvitz HR. Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science. 2000 Feb 25;287(5457):1485-9. PMID:10688797
  5. ↑ Yan N, Gu L, Kokel D, Chai J, Li W, Han A, Chen L, Xue D, Shi Y. Structural, biochemical, and functional analyses of CED-9 recognition by the proapoptotic proteins EGL-1 and CED-4. Mol Cell. 2004 Sep 24;15(6):999-1006. PMID:15383288 doi:10.1016/j.molcel.2004.08.022

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