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4mkp

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4mkp| PDB=4mkp | SCENE= }}
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===Crystal structure of human cGAS apo form===
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{{ABSTRACT_PUBMED_24116191}}
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The entry 4mkp is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CGAS_HUMAN CGAS_HUMAN]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.<ref>PMID:21478870</ref> <ref>PMID:23258413</ref>
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Authors: Kato, K., Ishii, R., Ishitani, R., Nureki, O.
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==About this Structure==
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[[4mkp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MKP OCA].
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Description: Crystal structure of human cGAS apo form
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==Reference==
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<ref group="xtra">PMID:024116191</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Ishii, R.]]
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[[Category: Ishitani, R.]]
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[[Category: Kato, K.]]
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[[Category: Nureki, O.]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Transferase]]

Revision as of 09:39, 30 October 2013

Template:STRUCTURE 4mkp

Contents

Crystal structure of human cGAS apo form

Template:ABSTRACT PUBMED 24116191

Function

[CGAS_HUMAN] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.[1] [2]

About this Structure

4mkp is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Kato K, Ishii R, Goto E, Ishitani R, Tokunaga F, Nureki O. Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS. PLoS One. 2013 Oct 7;8(10):e76983. doi: 10.1371/journal.pone.0076983. PMID:24116191 doi:http://dx.doi.org/10.1371/journal.pone.0076983
  1. ↑ Schoggins JW, Wilson SJ, Panis M, Murphy MY, Jones CT, Bieniasz P, Rice CM. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature. 2011 Apr 28;472(7344):481-5. doi: 10.1038/nature09907. Epub 2011 Apr 10. PMID:21478870 doi:10.1038/nature09907
  2. ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458

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