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1w9y
From Proteopedia
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| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:29:36 2007'' |
Revision as of 14:24, 30 October 2007
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THE STRUCTURE OF ACC OXIDASE
Overview
The final step in the biosynthesis of the plant signaling molecule, ethylene is catalyzed by 1-aminocyclopropane-1-carboxylic acid oxidase, (ACCO). ACCO requires bicarbonate as an activator and catalyzes the, oxidation of ACC to give ethylene, CO2, and HCN. We report crystal, structures of ACCO in apo-form (2.1 A resolution) and complexed with, Fe(II) (2.55 A) or Co(II) (2.4 A). The active site contains a single, Fe(II) ligated by three residues (His177, Asp179, and His234), and it is, relatively open compared to those of the 2-oxoglutarate oxygenases. The, side chains of Arg175 and Arg244, proposed to be involved in binding, bicarbonate, project away from the active site, but conformational changes, may allow either or both to enter the active site. The structures will, form a basis for ... [(full description)]
About this Structure
1W9Y is a [Single protein] structure of sequence from [Petunia x hybrida] with SO4 as [ligand]. Active as [Aminocyclopropanecarboxylate oxidase], with EC number [1.14.17.4]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme., Zhang Z, Ren JS, Clifton IJ, Schofield CJ, Chem Biol. 2004 Oct;11(10):1383-94. PMID:15489165
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