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4m4d

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'''Unreleased structure'''
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{{STRUCTURE_4m4d| PDB=4m4d | SCENE= }}
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===Crystal structure of lipopolysaccharide binding protein===
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{{ABSTRACT_PUBMED_24120359}}
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The entry 4m4d is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/LBP_MOUSE LBP_MOUSE]] Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity).
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Authors: Eckert, J.K., Kim, Y.J., Kim, J.I., Gurtler, K., Oh, D-Y, Ploeg, A.H., Pickkers, P., Lundvall, L., Hamann, L., Giamarellos-Bourboulis, E., Kubarenko, A.V., Weber, A.N., Kabesch, M., Kumpf, O., An, H.-J., Lee, J.-O., Schumann, R.R.
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==About this Structure==
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[[4m4d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4D OCA].
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Description: Crystal structure of lipopolysaccharide binding protein
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==Reference==
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<ref group="xtra">PMID:024120359</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: An, H J.]]
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[[Category: Eckert, J K.]]
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[[Category: Giamarellos-Bourboulis, E.]]
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[[Category: Gurtler, K.]]
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[[Category: Hamann, L.]]
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[[Category: Kabesch, M.]]
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[[Category: Kim, J I.]]
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[[Category: Kim, Y J.]]
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[[Category: Kubarenko, A V.]]
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[[Category: Kumpf, O.]]
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[[Category: Lee, J O.]]
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[[Category: Lundvall, L.]]
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[[Category: Oh, D Y.]]
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[[Category: Pickkers, P.]]
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[[Category: Ploeg, A H.]]
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[[Category: Schumann, R R.]]
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[[Category: Weber, A N.]]
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[[Category: Beta barrel]]
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[[Category: Blood]]
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[[Category: Immune response]]
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[[Category: Lipid binding protein]]
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[[Category: Lipopolysaccharide]]

Revision as of 09:44, 30 October 2013

Template:STRUCTURE 4m4d

Contents

Crystal structure of lipopolysaccharide binding protein

Template:ABSTRACT PUBMED 24120359

Function

[LBP_MOUSE] Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria, and acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity).

About this Structure

4m4d is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Eckert JK, Kim YJ, Kim JI, Gurtler K, Oh DY, Sur S, Lundvall L, Hamann L, van der Ploeg A, Pickkers P, Giamarellos-Bourboulis E, Kubarenko AV, Weber AN, Kabesch M, Kumpf O, An HJ, Lee JO, Schumann RR. The Crystal Structure of Lipopolysaccharide Binding Protein Reveals the Location of a Frequent Mutation that Impairs Innate Immunity. Immunity. 2013 Oct 17;39(4):647-60. doi: 10.1016/j.immuni.2013.09.005. Epub 2013 , Oct 10. PMID:24120359 doi:http://dx.doi.org/10.1016/j.immuni.2013.09.005

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