2pp4
From Proteopedia
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==Overview== | ==Overview== | ||
| - | The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human | + | The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into the mouse. One of these domains is related in sequence to TAF4, a component of TFIID. The structure of this domain, ETO-TAFH, is similar to yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related protein with structural similarity to the multisubunit RNA polymerases. Overlapping surfaces of ETO-TAFH interact with an autonomous repression domain of the nuclear receptor corepressor N-CoR and with a conserved activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and positive coregulatory proteins to control transcription. |
==About this Structure== | ==About this Structure== | ||
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[[Category: Liu, S.]] | [[Category: Liu, S.]] | ||
[[Category: Wei, Y.]] | [[Category: Wei, Y.]] | ||
| - | [[Category: Werner, M | + | [[Category: Werner, M H.]] |
[[Category: Woodrell, C.]] | [[Category: Woodrell, C.]] | ||
[[Category: Yokoyama, S.]] | [[Category: Yokoyama, S.]] | ||
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[[Category: transcriptional cofactor]] | [[Category: transcriptional cofactor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:31:46 2008'' |
Revision as of 16:31, 21 February 2008
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Solution Structure of ETO-TAFH refined in explicit solvent
Overview
The eight twenty-one protein, ETO, is implicated in 12%-15% of acute human leukemias as part of a gene fusion with RUNX1 (also called AML1). Of the four ETO domains related to Drosophila melanogaster Nervy, only two are required to induce spontaneous myeloid leukemia upon transplantation into the mouse. One of these domains is related in sequence to TAF4, a component of TFIID. The structure of this domain, ETO-TAFH, is similar to yeast Rpb4 and to Escherichia coli sigma(70); it is the first TAF-related protein with structural similarity to the multisubunit RNA polymerases. Overlapping surfaces of ETO-TAFH interact with an autonomous repression domain of the nuclear receptor corepressor N-CoR and with a conserved activation domain from the E-box family of transcription factors. Thus, ETO-TAFH acts as a structural platform that can interchange negative and positive coregulatory proteins to control transcription.
About this Structure
2PP4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription., Wei Y, Liu S, Lausen J, Woodrell C, Cho S, Biris N, Kobayashi N, Wei Y, Yokoyama S, Werner MH, Nat Struct Mol Biol. 2007 Jul;14(7):653-61. Epub 2007 Jun 17. PMID:17572682
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