2mf8

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m (Protected "2mf8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2mf8| PDB=2mf8 | SCENE= }}
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===HADDOCK model of MyT1 F4F5 - DNA complex===
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{{ABSTRACT_PUBMED_24097990}}
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The entry 2mf8 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/MYT1_MOUSE MYT1_MOUSE]] Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).<ref>PMID:9373037</ref>
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Authors: Gamsjaeger, R., O'Connell, M.R., Cubeddu, L., Shepherd, N.E., Lowry, J.A., Kwan, A.H., Vandevenne, M., Swanton, M.K., Matthews, J.M., Mackay, J.P.
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==About this Structure==
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[[2mf8]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MF8 OCA].
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Description: HADDOCK model of MyT1 F4F5 -DNA complex
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==Reference==
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<ref group="xtra">PMID:024097990</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Connell, M R.O.]]
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[[Category: Cubeddu, L.]]
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[[Category: Gamsjaeger, R.]]
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[[Category: Kwan, A H.]]
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[[Category: Lowry, J A.]]
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[[Category: Mackay, J P.]]
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[[Category: Matthews, J M.]]
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[[Category: Shepherd, N E.]]
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[[Category: Swanton, M K.]]
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[[Category: Vandevenne, M.]]
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[[Category: Metal binding protein-dna complex]]
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[[Category: Myt1]]
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[[Category: Zinc finger]]

Revision as of 07:35, 6 November 2013

Template:STRUCTURE 2mf8

Contents

HADDOCK model of MyT1 F4F5 - DNA complex

Template:ABSTRACT PUBMED 24097990

Function

[MYT1_MOUSE] Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity).[1]

About this Structure

2mf8 is a 3 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.

Reference

  • Gamsjaeger R, O'Connell MR, Cubeddu L, Shepherd NE, Lowry JA, Kwan AH, Vandevenne M, Swanton MK, Matthews JM, Mackay JP. A structural analysis of DNA binding by Myelin Transcription Factor 1 double zinc fingers. J Biol Chem. 2013 Oct 6. PMID:24097990 doi:http://dx.doi.org/10.1074/jbc.M113.482075
  1. ↑ Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD. Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. J Neurosci Res. 1997 Oct 15;50(2):272-90. PMID:9373037

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