This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4lrr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4lrr| PDB=4lrr | SCENE= }}
 +
===Ternary complex between E. coli thymidylate synthase, dUMP, and F9===
 +
{{ABSTRACT_PUBMED_24147825}}
-
The entry 4lrr is ON HOLD
+
==Function==
 +
[[http://www.uniprot.org/uniprot/TYSY_ECO57 TYSY_ECO57]] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).
-
Authors: Mangani, S., Pozzi, C., Ferrari, S., Costi, M.P.
+
==About this Structure==
 +
[[4lrr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_o157:h7 Escherichia coli o157:h7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRR OCA].
-
Description: Ternary complex between E. coli thymidylate synthase, dUMP, and F9
+
==Reference==
 +
<ref group="xtra">PMID:024147825</ref><references group="xtra"/><references/>
 +
[[Category: Escherichia coli o157:h7]]
 +
[[Category: Thymidylate synthase]]
 +
[[Category: Costi, M P.]]
 +
[[Category: Ferrari, S.]]
 +
[[Category: Mangani, S.]]
 +
[[Category: Pozzi, C.]]
 +
[[Category: Beta-mercaptoethanol modified cysteine]]
 +
[[Category: N-terminal acetylated methionine]]
 +
[[Category: Thymidine monophosphate synthesis]]
 +
[[Category: Transferase]]

Revision as of 07:51, 6 November 2013

Template:STRUCTURE 4lrr

Contents

Ternary complex between E. coli thymidylate synthase, dUMP, and F9

Template:ABSTRACT PUBMED 24147825

Function

[TYSY_ECO57] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

About this Structure

4lrr is a 1 chain structure with sequence from Escherichia coli o157:h7. Full crystallographic information is available from OCA.

Reference

  • Ferrari S, Calo S, Leone R, Luciani R, Costantino L, Sammak S, Di Pisa F, Pozzi C, Mangani S, Costi MP. 2'-deoxyuridine-5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives. J Med Chem. 2013 Oct 22. PMID:24147825 doi:http://dx.doi.org/10.1021/jm4014086

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lrr"
Personal tools