4ior

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{{STRUCTURE_4ior| PDB=4ior | SCENE= }}
{{STRUCTURE_4ior| PDB=4ior | SCENE= }}
===Crystal Structure of the first bromodomain of BRD4 in complex with DMSO===
===Crystal Structure of the first bromodomain of BRD4 in complex with DMSO===
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{{ABSTRACT_PUBMED_24100334}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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[[4ior]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOR OCA].
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[[4ior]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IOR OCA].
==Reference==
==Reference==
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<references group="xtra"/><references/>
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<ref group="xtra">PMID:024100334</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Battistutta, R.]]
[[Category: Battistutta, R.]]
[[Category: Lolli, G.]]
[[Category: Lolli, G.]]

Revision as of 06:15, 13 November 2013

Template:STRUCTURE 4ior

Contents

Crystal Structure of the first bromodomain of BRD4 in complex with DMSO

Template:ABSTRACT PUBMED 24100334

Disease

[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]

Function

[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).

About this Structure

4ior is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Lolli G, Battistutta R. Different orientations of low-molecular-weight fragments in the binding pocket of a BRD4 bromodomain. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2161-4. doi:, 10.1107/S090744491301994X. Epub 2013 Sep 20. PMID:24100334 doi:http://dx.doi.org/10.1107/S090744491301994X
  1. ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
  2. ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0

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