This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4lcv
From Proteopedia
| Line 7: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4lcv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4lcv]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCV OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023994332</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023994332</ref><references group="xtra"/><references/> | ||
| - | [[Category: | + | [[Category: Buffalo rat]] |
[[Category: Almagor, L.]] | [[Category: Almagor, L.]] | ||
[[Category: Giladi, M.]] | [[Category: Giladi, M.]] | ||
Revision as of 06:15, 13 November 2013
Contents |
Crystal Structure of DOC2B C2A domain
Template:ABSTRACT PUBMED 23994332
Function
[DOC2B_RAT] Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.[1] [2]
About this Structure
4lcv is a 4 chain structure with sequence from Buffalo rat. Full crystallographic information is available from OCA.
Reference
- Giladi M, Michaely L, Almagor L, Bar-On D, Buki T, Ashery U, Khananshvili D, Hirsch JA. The C2B Domain Is the Primary Ca Sensor in DOC2B: A Structural and Functional Analysis. J Mol Biol. 2013 Aug 28. pii: S0022-2836(13)00537-8. doi:, 10.1016/j.jmb.2013.08.017. PMID:23994332 doi:10.1016/j.jmb.2013.08.017
- ↑ Friedrich R, Groffen AJ, Connell E, van Weering JR, Gutman O, Henis YI, Davletov B, Ashery U. DOC2B acts as a calcium switch and enhances vesicle fusion. J Neurosci. 2008 Jul 2;28(27):6794-806. doi: 10.1523/JNEUROSCI.0538-08.2008. PMID:18596155 doi:10.1523/JNEUROSCI.0538-08.2008
- ↑ Groffen AJ, Martens S, Diez Arazola R, Cornelisse LN, Lozovaya N, de Jong AP, Goriounova NA, Habets RL, Takai Y, Borst JG, Brose N, McMahon HT, Verhage M. Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science. 2010 Mar 26;327(5973):1614-8. doi: 10.1126/science.1183765. Epub 2010, Feb 11. PMID:20150444 doi:10.1126/science.1183765
