1wc7
From Proteopedia
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Revision as of 14:26, 30 October 2007
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FAB FRAGMENT OF PLP-DEPENDENT CATALYTIC ANTIBODY 15A9 IN COMPLEX WITH PHOSPHOPYRIDOXYL-L-ALANINE
Overview
The purification, crystallization and structure determination at 2.3 A, resolution of the complex of the pyridoxal-5'-phosphate (PLP) dependent, catalytic antibody 15A9 with a phosphopyridoxyl-L-alanine (PPL-L-alanine), substrate analogue are described. The crystal belongs to space group, P2(1), with two molecules in the asymmetric unit related by, non-crystallographic symmetry. The unit-cell parameters are a = 63.5, b =, 81.7, c = 79.3 A and beta is fortuitously 90 degrees . Refinement of the, structure converged at unacceptably high R factors. Although the, traditional analysis of intensity distribution did not indicate twinning, pseudomerohedral twinning was revealed by a newer test based on local, intensity differences [Padilla & Yeates (2003), Acta Cryst. D59, 1124-1130]. When ... [(full description)]
About this Structure
1WC7 is a [Single protein] structure of sequence from [Mus musculus] with IOD and PP3 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Structure of a pseudomerohedrally twinned monoclinic crystal form of a pyridoxal phosphate-dependent catalytic antibody., Golinelli-Pimpaneau B, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):472-6. Epub 2005, Mar 24. PMID:15805602
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