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4m2s

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'''Unreleased structure'''
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{{STRUCTURE_4m2s| PDB=4m2s | SCENE= }}
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===Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR===
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{{ABSTRACT_PUBMED_24155053}}
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The entry 4m2s is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/MDR1A_MOUSE MDR1A_MOUSE]] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.<ref>PMID:19325113</ref>
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Authors: Li, J., Jaimes, K.F., Aller, S.G.
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==About this Structure==
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[[4m2s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M2S OCA].
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Description: Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR
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==Reference==
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<ref group="xtra">PMID:024155053</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
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[[Category: Xenobiotic-transporting ATPase]]
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[[Category: Aller, S G.]]
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[[Category: Jaimes, K F.]]
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[[Category: Li, J.]]
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[[Category: Adenosine triphosphate]]
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[[Category: Atp-binding cassette transporter]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Multidrug efflux]]

Revision as of 08:16, 13 November 2013

Template:STRUCTURE 4m2s

Contents

Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR

Template:ABSTRACT PUBMED 24155053

Function

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]

About this Structure

4m2s is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718

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OCA

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