This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4hmn
From Proteopedia
| Line 1: | Line 1: | ||
| - | + | {{STRUCTURE_4hmn| PDB=4hmn | SCENE= }} | |
| + | ===Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone. | ||
| - | + | ==About this Structure== | |
| - | + | [[4hmn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HMN OCA]. | |
| - | + | [[Category: Atwell, G J.]] | |
| + | [[Category: Brooke, D G.]] | ||
| + | [[Category: Denny, W A.]] | ||
| + | [[Category: Flanagan, J U.]] | ||
| + | [[Category: Heinrich, D M.]] | ||
| + | [[Category: Jamieson, S M.F.]] | ||
| + | [[Category: Owen, P J.]] | ||
| + | [[Category: Raynham, T.]] | ||
| + | [[Category: Rigoreau, L J.M.]] | ||
| + | [[Category: Samlal, S S.]] | ||
| + | [[Category: Schroeder, E.]] | ||
| + | [[Category: Silva, S.]] | ||
| + | [[Category: Soudy, C.]] | ||
| + | [[Category: Trivier, E.]] | ||
| + | [[Category: Turnbull, A P.]] | ||
| + | [[Category: Aldo-keto reductase]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | ||
| + | [[Category: Tim-barrel]] | ||
Revision as of 08:26, 13 November 2013
Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with (4-(4-Chlorophenyl)piperazin-1-yl)(morpholino)methanone (24)
Function
[AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
About this Structure
4hmn is a 1 chain structure. Full crystallographic information is available from OCA.
Categories: Atwell, G J. | Brooke, D G. | Denny, W A. | Flanagan, J U. | Heinrich, D M. | Jamieson, S M.F. | Owen, P J. | Raynham, T. | Rigoreau, L J.M. | Samlal, S S. | Schroeder, E. | Silva, S. | Soudy, C. | Trivier, E. | Turnbull, A P. | Aldo-keto reductase | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex | Tim-barrel
