1w6j
From Proteopedia
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| - | [[Image:1w6j.png|left|200px]] | ||
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{{STRUCTURE_1w6j| PDB=1w6j | SCENE= }} | {{STRUCTURE_1w6j| PDB=1w6j | SCENE= }} | ||
| + | ===Structure of human OSC in complex with Ro 48-8071=== | ||
| + | {{ABSTRACT_PUBMED_15525992}} | ||
| - | == | + | ==Function== |
| - | + | [[http://www.uniprot.org/uniprot/ERG7_HUMAN ERG7_HUMAN]] Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.<ref>PMID:7639730</ref> | |
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==About this Structure== | ==About this Structure== | ||
| - | [[1w6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[1w6j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W6J OCA]. |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:015525992</ref>< | + | <ref group="xtra">PMID:015525992</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Lanosterol synthase]] | [[Category: Lanosterol synthase]] | ||
[[Category: Aebi, J.]] | [[Category: Aebi, J.]] | ||
| - | [[Category: Arcy, B D | + | [[Category: Arcy, B D]] |
[[Category: Benz, J.]] | [[Category: Benz, J.]] | ||
[[Category: Dehmlow, H.]] | [[Category: Dehmlow, H.]] | ||
Revision as of 11:38, 20 November 2013
Contents |
Structure of human OSC in complex with Ro 48-8071
Template:ABSTRACT PUBMED 15525992
Function
[ERG7_HUMAN] Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.[1]
About this Structure
1w6j is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A. Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase. Nature. 2004 Nov 4;432(7013):118-22. PMID:15525992 doi:10.1038/nature02993
- ↑ Baker CH, Matsuda SP, Liu DR, Corey EJ. Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library. Biochem Biophys Res Commun. 1995 Aug 4;213(1):154-60. PMID:7639730 doi:http://dx.doi.org/S0006-291X(85)72110-9
