1xpt
From Proteopedia
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[[Category: hydrolase (phosphoric diester)]] | [[Category: hydrolase (phosphoric diester)]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 16:32:34 2007'' |
Revision as of 14:27, 30 October 2007
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BOVINE RIBONUCLEASE A (PHOSPHATE-FREE)
Overview
The structures of a new crystal form of ribonuclease A and its, low-humidity variant, each containing two crystallographically independent, molecules, have been determined and refined. A detailed comparison of, these structures with those of the other known crystal forms of the, enzyme, which have different packing arrangements and solvent composition, leads to a meaningful delineation of the rigid and flexible regions of the, protein molecule and the nature of its plasticity. Many of the water, molecules which are common to all the structures are involved in bridging, different regions of the protein molecule, thus emphasizing the role of, water in stabilizing the tertiary structure. The analysis of the, structures shows that for a given N or O atom, the level of hydration, increases ... [(full description)]
About this Structure
1XPT is a [Single protein] structure of sequence from [Bos taurus]. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Site: ACT. Full crystallographic information is available from [OCA].
Reference
Plasticity, hydration and accessibility in ribonuclease A. The structure of a new crystal form and its low-humidity variant., Sadasivan C, Nagendra HG, Vijayan M, Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1343-52. PMID:10089510
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