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4bj3
From Proteopedia
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| - | + | {{STRUCTURE_4bj3| PDB=4bj3 | SCENE= }} | |
| + | ===Integrin alpha2 I domain E318W-collagen complex=== | ||
| + | {{ABSTRACT_PUBMED_23922814}} | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/ITA2_HUMAN ITA2_HUMAN]] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. | ||
| - | + | ==About this Structure== | |
| + | [[4bj3]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BJ3 OCA]. | ||
| - | + | ==Reference== | |
| + | <ref group="xtra">PMID:023922814</ref><references group="xtra"/><references/> | ||
| + | [[Category: Bihan, D.]] | ||
| + | [[Category: Carafoli, F.]] | ||
| + | [[Category: Farndale, R W.]] | ||
| + | [[Category: Hamaia, S W.]] | ||
| + | [[Category: Hohenester, E.]] | ||
| + | [[Category: Cell adhesion]] | ||
Revision as of 13:34, 20 November 2013
Contents |
Integrin alpha2 I domain E318W-collagen complex
Template:ABSTRACT PUBMED 23922814
Function
[ITA2_HUMAN] Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
About this Structure
4bj3 is a 5 chain structure. Full crystallographic information is available from OCA.
Reference
- Carafoli F, Hamaia SW, Bihan D, Hohenester E, Farndale RW. An activating mutation reveals a second binding mode of the integrin alpha2 I domain to the GFOGER motif in collagens. PLoS One. 2013 Jul 29;8(7):e69833. doi: 10.1371/journal.pone.0069833. Print 2013. PMID:23922814 doi:http://dx.doi.org/10.1371/journal.pone.0069833
