This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4bmj
From Proteopedia
| Line 1: | Line 1: | ||
{{STRUCTURE_4bmj| PDB=4bmj | SCENE= }} | {{STRUCTURE_4bmj| PDB=4bmj | SCENE= }} | ||
===Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1=== | ===Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1=== | ||
| + | {{ABSTRACT_PUBMED_24239949}} | ||
==Function== | ==Function== | ||
| Line 6: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4bmj]] is a 11 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA]. | + | [[4bmj]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BMJ OCA]. |
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024239949</ref><references group="xtra"/><references/> |
| + | [[Category: Human]] | ||
[[Category: Bravo, J.]] | [[Category: Bravo, J.]] | ||
[[Category: Buts, L.]] | [[Category: Buts, L.]] | ||
Revision as of 08:32, 27 November 2013
Contents |
Structure of the UBZ1and2 tandem of the ubiquitin-binding adaptor protein TAX1BP1
Template:ABSTRACT PUBMED 24239949
Function
[TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.[1] [2]
About this Structure
4bmj is a 11 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Ceregido MA, Spinola Amilibia M, Buts L, Rivera-Torres J, Garcia-Pino A, Bravo J, van Nuland NA. The Structure of TAX1BP1 UBZ1+2 Provides Insight into Target Specificity and Adaptability. J Mol Biol. 2013 Nov 13. pii: S0022-2836(13)00717-1. doi:, 10.1016/j.jmb.2013.11.006. PMID:24239949 doi:http://dx.doi.org/10.1016/j.jmb.2013.11.006
- ↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90. PMID:10435631 doi:http://dx.doi.org/10.1038/sj.onc.1202787
- ↑ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72. PMID:10920205 doi:http://dx.doi.org/10.1073/pnas.170279097
