4jiz

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{{STRUCTURE_4jiz| PDB=4jiz | SCENE= }}
{{STRUCTURE_4jiz| PDB=4jiz | SCENE= }}
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===Human Mob1-phsophopeptide complex===
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===Human Mob1-phosphopeptide complex===
{{ABSTRACT_PUBMED_23579499}}
{{ABSTRACT_PUBMED_23579499}}
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==About this Structure==
==About this Structure==
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[[4jiz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIZ OCA].
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[[4jiz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JIZ OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:023579499</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:023579499</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Amon, A.]]
[[Category: Amon, A.]]
[[Category: Lim, D]]
[[Category: Lim, D]]

Revision as of 08:35, 27 November 2013

Template:STRUCTURE 4jiz

Contents

Human Mob1-phosphopeptide complex

Template:ABSTRACT PUBMED 23579499

Function

[MOB1A_HUMAN] Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.[1] [2] [3]

About this Structure

4jiz is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A. Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes. Science. 2013 Apr 11. PMID:23579499 doi:10.1126/science.1235822
  1. ↑ Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. J Biol Chem. 2004 Aug 20;279(34):35228-35. Epub 2004 Jun 14. PMID:15197186 doi:10.1074/jbc.M404542200
  2. ↑ Hirabayashi S, Nakagawa K, Sumita K, Hidaka S, Kawai T, Ikeda M, Kawata A, Ohno K, Hata Y. Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene. 2008 Jul 17;27(31):4281-92. doi: 10.1038/onc.2008.66. Epub 2008 Mar 24. PMID:18362890 doi:10.1038/onc.2008.66
  3. ↑ Chow A, Hao Y, Yang X. Molecular characterization of human homologs of yeast MOB1. Int J Cancer. 2010 May 1;126(9):2079-89. doi: 10.1002/ijc.24878. PMID:19739119 doi:10.1002/ijc.24878

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