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4c50

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==About this Structure==
==About this Structure==
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[[4c50]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C50 OCA].
+
[[4c50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_sp._h37rv Mycobacterium sp. h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C50 OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024185282</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024185282</ref><references group="xtra"/><references/>
[[Category: Catalase peroxidase]]
[[Category: Catalase peroxidase]]
 +
[[Category: Mycobacterium sp. h37rv]]
[[Category: Andersson, K K.]]
[[Category: Andersson, K K.]]
[[Category: Hersleth, H P.]]
[[Category: Hersleth, H P.]]

Revision as of 09:00, 27 November 2013

Template:STRUCTURE 4c50

Contents

Crystal Structure of the Catalase-Peroxidase (KatG) D137S mutant from Mycobacterium Tuberculosis

Template:ABSTRACT PUBMED 24185282

Function

[KATG_MYCTU] Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid (INH) lyase and isonicotinoyl-NAD synthase activity. May play a role in the intracellular survival of mycobacteria. May be involved in DNA repair. Partly complements recA-deficient E.coli cells exposed to UV radiation, mitomycin C or hydrogen peroxide. Increases resistance to mitomycin C in E.coli cells deficient for either uvrA, uvrB or uvrC.[1]

About this Structure

4c50 is a 2 chain structure with sequence from Mycobacterium sp. h37rv. Full crystallographic information is available from OCA.

Reference

  • Zhao X, Hersleth HP, Zhu J, Andersson KK, Magliozzo RS. Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid. Chem Commun (Camb). 2013 Nov 4. PMID:24185282 doi:http://dx.doi.org/10.1039/c3cc47022a
  1. ↑ Mulder MA, Nair S, Abratt VR, Zappe H, Steyn LM. Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents. Microbiology. 1999 Aug;145 ( Pt 8):2011-21. PMID:10463167

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