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| - | {{STRUCTURE_4hol| PDB=4hol | SCENE= }}
| + | #REDIRECT [[4naq]] This PDB entry is obsolete and replaced by 4naq |
| - | ===Crystal structure of porcine aminopeptidase-N complexed with poly-alanine===
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| - | {{ABSTRACT_PUBMED_23071329}}
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| - | ==Function==
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| - | [[http://www.uniprot.org/uniprot/AMPN_PIG AMPN_PIG]] Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines and involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis (By similarity). It is able to degrade Leu-enkephalin and Met-enkephalin but not cholecystokinin CCK8, neuromedin C (GRP-10), somatostatin-14, substance P and vasoactive intestinal peptide. In case of porcine transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCoV) infections, serves as a receptor for TGEV and PRCoV spike glycoprotein in a species-specific manner.<ref>PMID:7913510</ref> <ref>PMID:1350661</ref> <ref>PMID:7911642</ref> <ref>PMID:8985407</ref> <ref>PMID:9634079</ref> | + | |
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| - | ==About this Structure==
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| - | [[4hol]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4fkf 4fkf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HOL OCA].
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| - | ==See Also==
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| - | *[[Aminopeptidase|Aminopeptidase]]
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| - | ==Reference==
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| - | <references group="xtra"/><references/>
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| - | [[Category: Membrane alanyl aminopeptidase]]
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| - | [[Category: Sus scrofa]]
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| - | [[Category: Chen, L.]]
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| - | [[Category: Li, F.]]
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| - | [[Category: Lin, Y L.]]
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| - | [[Category: Peng, G.]]
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| - | [[Category: Hydrolase]]
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| - | [[Category: Zinc aminopeptidase]]
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Current revision
- REDIRECT 4naq This PDB entry is obsolete and replaced by 4naq
