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3wk3

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'''Unreleased structure'''
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{{STRUCTURE_3wk3| PDB=3wk3 | SCENE= }}
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===Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate ethyl ester===
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{{ABSTRACT_PUBMED_24151964}}
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The entry 3wk3 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PYRF_METTH PYRF_METTH]] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]
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Authors: Fujihashi, M., Pai, E.F., Miki, K.
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==About this Structure==
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[[3wk3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WK3 OCA].
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Description: Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate ethyl ester
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==Reference==
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<ref group="xtra">PMID:024151964</ref><references group="xtra"/><references/>
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[[Category: Orotidine-5'-phosphate decarboxylase]]
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[[Category: Fujihashi, M.]]
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[[Category: Miki, K.]]
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[[Category: Pai, E F.]]
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[[Category: Decarboxylase]]
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[[Category: Lyase]]
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[[Category: Protein-ligand complex]]
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[[Category: Pyrimidine biosynthesis]]
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[[Category: Tim barrel]]

Revision as of 07:18, 4 December 2013

Template:STRUCTURE 3wk3

Contents

Orotidine 5'-monophosphate decarboxylase K72A mutant from M. thermoautotrophicus complexed with orotidine 5'-monophosphate ethyl ester

Template:ABSTRACT PUBMED 24151964

Function

[PYRF_METTH] Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).[HAMAP-Rule:MF_01200_A]

About this Structure

3wk3 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Fujihashi M, Ishida T, Kuroda S, Kotra LP, Pai EF, Miki K. Substrate distortion contributes to the catalysis of orotidine 5'-monophosphate decarboxylase. J Am Chem Soc. 2013 Nov 20;135(46):17432-43. doi: 10.1021/ja408197k. Epub 2013, Nov 11. PMID:24151964 doi:http://dx.doi.org/10.1021/ja408197k

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OCA

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