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4c2c

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4c2c| PDB=4c2c | SCENE= }}
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===Crystal structure of the protease CtpB in an active state===
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{{ABSTRACT_PUBMED_24243021}}
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The entry 4c2c is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref>
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Authors: Mastny, M., Heuck, A., Kurzbauer, R., Clausen, T.
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==About this Structure==
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[[4c2c]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2C OCA].
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Description: Crystal structure of the protease CtpB in an active state
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==Reference==
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<ref group="xtra">PMID:024243021</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli]]
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[[Category: Clausen, T.]]
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[[Category: Heuck, A.]]
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[[Category: Kurzbauer, R.]]
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[[Category: Mastny, M.]]
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[[Category: Allosteric regulation]]
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[[Category: Conformational switch]]
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[[Category: Hydrolase]]
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[[Category: Pdz-protease]]
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[[Category: Proteolytic tunnel]]
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[[Category: Sporulation]]

Revision as of 07:19, 4 December 2013

Template:STRUCTURE 4c2c

Contents

Crystal structure of the protease CtpB in an active state

Template:ABSTRACT PUBMED 24243021

Function

[CTPB_BACSU] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.[1] [2] [3]

About this Structure

4c2c is a 3 chain structure with sequence from [1] and Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T. CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis. Cell. 2013 Oct 24;155(3):647-58. doi: 10.1016/j.cell.2013.09.050. Epub 2013 Oct, 24. PMID:24243021 doi:http://dx.doi.org/10.1016/j.cell.2013.09.050
  1. ↑ Pan Q, Losick R, Rudner DZ. A second PDZ-containing serine protease contributes to activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2003 Oct;185(20):6051-6. PMID:14526016
  2. ↑ Campo N, Rudner DZ. A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis. Mol Cell. 2006 Jul 7;23(1):25-35. PMID:16818230 doi:http://dx.doi.org/10.1016/j.molcel.2006.05.019
  3. ↑ Campo N, Rudner DZ. SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2007 Aug;189(16):6021-7. Epub 2007 Jun 8. PMID:17557826 doi:http://dx.doi.org/10.1128/JB.00399-07

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