This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4c2g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4c2g" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_4c2g| PDB=4c2g | SCENE= }}
 +
===Crystal structure of CtpB(S309A) in complex with a peptide having a Val-Pro-Ala C-terminus===
 +
{{ABSTRACT_PUBMED_24243021}}
-
The entry 4c2g is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/CTPB_BACSU CTPB_BACSU]] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.<ref>PMID:14526016</ref> <ref>PMID:16818230</ref> <ref>PMID:17557826</ref>
-
Authors: Mastny, M., Heuck, A., Kurzbauer, R., Clausen, T.
+
==About this Structure==
 +
[[4c2g]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C2G OCA].
-
Description: Crystal structure of CtpB(S309A) in complex with a peptide having a Val-Pro-Ala C-terminus
+
==Reference==
 +
<ref group="xtra">PMID:024243021</ref><references group="xtra"/><references/>
 +
[[Category: C-terminal processing peptidase]]
 +
[[Category: Escherichia coli]]
 +
[[Category: Clausen, T.]]
 +
[[Category: Heuck, A.]]
 +
[[Category: Kurzbauer, R.]]
 +
[[Category: Mastny, M.]]
 +
[[Category: Allosteric regulation]]
 +
[[Category: Conformational switch]]
 +
[[Category: Hydrolase-peptide complex]]
 +
[[Category: Pdz-protease]]
 +
[[Category: Proteolytic tunnel]]
 +
[[Category: Sporulation]]

Revision as of 07:24, 4 December 2013

Template:STRUCTURE 4c2g

Contents

Crystal structure of CtpB(S309A) in complex with a peptide having a Val-Pro-Ala C-terminus

Template:ABSTRACT PUBMED 24243021

Function

[CTPB_BACSU] Involved in the signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. The signaling serine protease CtpB triggers pro-sigma-K processing by cleaving the regulatory protein SpoIVFA and is necessary for the proper timing of sigma-K activation.[1] [2] [3]

About this Structure

4c2g is a 3 chain structure with sequence from [1] and Escherichia coli. Full crystallographic information is available from OCA.

Reference

  • Mastny M, Heuck A, Kurzbauer R, Heiduk A, Boisguerin P, Volkmer R, Ehrmann M, Rodrigues CD, Rudner DZ, Clausen T. CtpB Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling during Spore Formation in Bacillus subtilis. Cell. 2013 Oct 24;155(3):647-58. doi: 10.1016/j.cell.2013.09.050. Epub 2013 Oct, 24. PMID:24243021 doi:http://dx.doi.org/10.1016/j.cell.2013.09.050
  1. ↑ Pan Q, Losick R, Rudner DZ. A second PDZ-containing serine protease contributes to activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2003 Oct;185(20):6051-6. PMID:14526016
  2. ↑ Campo N, Rudner DZ. A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis. Mol Cell. 2006 Jul 7;23(1):25-35. PMID:16818230 doi:http://dx.doi.org/10.1016/j.molcel.2006.05.019
  3. ↑ Campo N, Rudner DZ. SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor sigmaK in Bacillus subtilis. J Bacteriol. 2007 Aug;189(16):6021-7. Epub 2007 Jun 8. PMID:17557826 doi:http://dx.doi.org/10.1128/JB.00399-07

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4c2g"
Personal tools