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4c8d
From Proteopedia
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{{STRUCTURE_4c8d| PDB=4c8d | SCENE= }} | {{STRUCTURE_4c8d| PDB=4c8d | SCENE= }} | ||
===Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)=== | ===Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)=== | ||
| + | |||
| + | ==Function== | ||
| + | [[http://www.uniprot.org/uniprot/KDM3B_HUMAN KDM3B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.<ref>PMID:16603237</ref> | ||
==About this Structure== | ==About this Structure== | ||
| - | [[4c8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4c8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8D OCA]. |
| - | [[Category: | + | |
| + | ==Reference== | ||
| + | <references group="xtra"/><references/> | ||
| + | [[Category: Human]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
[[Category: Bountra, C.]] | [[Category: Bountra, C.]] | ||
Revision as of 12:36, 11 December 2013
Contents |
Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)
Function
[KDM3B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.[1]
About this Structure
4c8d is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- ↑ Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell. 2006 May 5;125(3):483-95. Epub 2006 Apr 6. PMID:16603237 doi:http://dx.doi.org/S0092-8674(06)00385-0
