Glucosamine 6-phosphate synthase
From Proteopedia
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| - | <StructureSection load='1moq' size='400' side='right' caption='Structure of glucosamine 6-phosphate synthase complex with glucosamine-6-phosphate, sulfate and Na+ (PDB entry [[1moq]])' scene=''> | + | <StructureSection load='1moq' size='400' side='right' caption='Structure of glucosamine 6-phosphate synthase complex with glucosamine-6-phosphate, sulfate and Na+ (purple) (PDB entry [[1moq]])' scene=''> |
'''Glucosamine 6-phosphate synthase''' (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P). N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. The most potent inhibitor of G6PS is the intermediate analog amino-2-deoxy-D-glucitol 6-phosphate (ADGP). | '''Glucosamine 6-phosphate synthase''' (G6PS) catalyzes the first step in the biosynthesis of UDP-GlcNAc. G6PS converts fructose-6-phosphate (F6P) and glutamine to glucosamine-6-phosphate (G6P). N-acetylglucosamine is an essential building block of chitin which comprises the bacterial and fungal cell wall. Hence, G6PS is a target to anti-bacterial and anti-fungal agents. The most potent inhibitor of G6PS is the intermediate analog amino-2-deoxy-D-glucitol 6-phosphate (ADGP). | ||
Revision as of 07:28, 15 December 2013
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