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4fcj
From Proteopedia
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{{STRUCTURE_4fcj| PDB=4fcj | SCENE= }} | {{STRUCTURE_4fcj| PDB=4fcj | SCENE= }} | ||
===Crystal structure of the NTF2-like domain of human G3BP1=== | ===Crystal structure of the NTF2-like domain of human G3BP1=== | ||
| + | {{ABSTRACT_PUBMED_24324649}} | ||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
| - | [[4fcj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4fcj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FCJ OCA]. |
==Reference== | ==Reference== | ||
| - | <references group="xtra"/><references/> | + | <ref group="xtra">PMID:024324649</ref><references group="xtra"/><references/> |
| - | [[Category: | + | [[Category: Human]] |
[[Category: Kristensen, O.]] | [[Category: Kristensen, O.]] | ||
[[Category: Vognsen, T.]] | [[Category: Vognsen, T.]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Ntf2-like domain]] | [[Category: Ntf2-like domain]] | ||
Revision as of 08:19, 18 December 2013
Contents |
Crystal structure of the NTF2-like domain of human G3BP1
Template:ABSTRACT PUBMED 24324649
Function
[G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.[1] [2]
About this Structure
4fcj is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Vognsen T, Moller IR, Kristensen O. Crystal Structures of the Human G3BP1 NTF2-Like Domain Visualize FxFG Nup Repeat Specificity. PLoS One. 2013 Dec 4;8(12):e80947. doi: 10.1371/journal.pone.0080947. PMID:24324649 doi:http://dx.doi.org/10.1371/journal.pone.0080947
- ↑ Costa M, Ochem A, Staub A, Falaschi A. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway. Nucleic Acids Res. 1999 Feb 1;27(3):817-21. PMID:9889278
- ↑ Tourriere H, Gallouzi IE, Chebli K, Capony JP, Mouaikel J, van der Geer P, Tazi J. RasGAP-associated endoribonuclease G3Bp: selective RNA degradation and phosphorylation-dependent localization. Mol Cell Biol. 2001 Nov;21(22):7747-60. PMID:11604510 doi:10.1128/MCB.21.22.7747-7760.2001
